Table 1—

Surrogate parameters of subclinical inflammation in patients with obstructive sleep apnoea syndrome(OSAS)

	IL-6	IL-6 + CRP^#	IL-6	CRP	CRP
First author [Ref.]	Vgontzas [37]	Yokoe [32]	Imagawa [36]	Guilleminault [34]	Kokturk [33]
Status *versus* controls	Elevated	Elevated	Normal	Normal	Elevated
Patients n	12	30	110	156	94 (OSAS with CVD); 56 (OSAS without CVD)
Mean BMI	40.5	27.5	26	29.4	32
Correlation with BMI	+	+	+	+	+
Correlation with AHI	-	+	+	-	-

IL: interleukin; CRP: C-reactive protein; CVD: cardiovascular disease; BMI: body mass index; +: significant positive correlation; -: no correlation; AHI: apnoea/hypopnoea index. ^#: improvement of these parameters occurred after 1 month of nasal continuous positive airway pressure therapy.