ETA receptor | ETB receptor |
Afferent arteriolar constriction# | Medullary vasodilation |
Efferent arteriolar dilation# | Afferent arteriolar constriction# |
Mesangial cell contraction | Efferent arteriolar dilation# |
Mesangial cell proliferation | Natriuresis |
Extracellular matrix accumulation | Diuresis |
Interstitial fibrosis | Acid excretion↑ |
#: effect depends on ET-1 concentration. Higher doses: afferent + efferent constriction (ultrafiltration pressure ↓), contraction mesangial cell (glomerular ultrafiltration ↓) → glomerular filtration rate ↓. Lower doses: efferent > afferent constriction (ultrafiltration pressure ↑), contraction mesangial cell (glomerular ultrafiltration ↓) → glomerular filtration rate ↔.