OM-85 and exacerbations of chronic bronchitis and chronic obstructive pulmonary disease
| Author | Year | Treatment | Patients | FEV1 % pred | Exac.·Patient | Δ% | p-value |
| Collet# [20] | 1997 | OM-85 | 191 | 42 | 0.57 (287) | 0 | ns |
| Placebo | 190 | 44 | 0.57 (642) | (−55) | |||
| Orcel¶ [21] | 1994 | OM-85 | 147 | 55 | 112 LRTIs | −28 | 0.05 |
| Placebo | 143 | 55 | 156 LRTIs | ||||
| Solèr+ [22] | 2004 | OM-85 | 142 | 85 | 0.61 Exac.·pat. | −29 | 0.03 |
| Placebo | 131 | 83 | 0.86 Exac.·pat. |
FEV1: forced expiratory volume in one second; % pred: % predicted; Exac: exacerbations; LRTI: lower respiratory tract infections; ns: nonsignificant. #: data presented as the number of exacerbations per patient, followed by the number of hospital days due to exacerbations for the whole treatment group; ¶: number of exacerbations for both treatment groups; +: number of exacerbations per patient.