Control and monocrotaline(MCT) treated rats
| Control | MCT+vehicle | MCT+sorafenib | |
| RVP mmHg | 27.0±0.5* | 82.9±6.0 | 35.0±1.5* |
| RVEDP mmHg | 2.0±0.2* | 7.7±1.3 | 2.6±0.2* |
| RV/(LV+S) | 0.24±0.01* | 0.51±0.02 | 0.26±0.01* |
| CO mL·min−1 | 116.1±5.1* | 70.5±6.7 | 117.4±5.3* |
| P a,O2mmHg | 204.8±18.5* | 107.7±13.8 | 200.0±10.4* |
Data are presented as mean±sem. RVP: right ventricular pressure; RVEDP: right ventricular end-diastolic pressure; RV/(LV+S): ratio of right ventricle to left ventricle plus sputum; CO: cardiac output; Pa,O2: arterial oxygen tension. In each group, n = 12–14. *: p<0.05 versus vehicle.