PT  - JOURNAL ARTICLE
AU  - Dhiren F. Patel
AU  - Robert J. Snelgrove
TI  - The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease
AID  - 10.1183/16000617.0017-2018
DP  - 2018 Jun 30
TA  - European Respiratory Review
PG  - 180017
VI  - 27
IP  - 148
4099  - http://err.ersjournals.com/content/27/148/180017.short
4100  - http://err.ersjournals.com/content/27/148/180017.full
SO  - EUROPEAN RESPIRATORY REVIEW2018 Jun 30; 27
AB  - Matrikines are bioactive fragments of the extracellular matrix (ECM) that are fundamental in regulating a diverse array of physiological processes. The tripeptide Proline-Glycine-Proline (PGP) is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. In this article, we describe our current understanding of the pathways that generate, degrade and modify PGP to dictate its bioavailability and stability. Additionally, we discuss our expanding appreciation of the capacity of PGP to regulate diverse cell types and biological processes, independent of its activity on neutrophils, including a putative role in wound repair. We argue that PGP functions as a primitive and conserved damage-associated molecular pattern, which is generated during infection or injury and subsequently acts to shape ensuing inflammatory and repair processes. As a fragment of the ECM that accumulates at the epicentre of the action, PGP is perfectly positioned to focus neutrophils to the exact site required and direct a localised repair response. However, it is essential that PGP is efficiently degraded, as if this matrikine is allowed to persist then pathology can ensue. Accordingly, we discuss how this pathway is subverted in chronic lung diseases giving rise to persistent inflammation and pathological tissue remodelling.The matrikine Pro-Gly-Pro regulates pulmonary inflammation and repair, but its persistence can drive pathology http://ow.ly/vUbo30kswVO