RT Journal Article
SR Electronic
T1 The role of cardiopulmonary exercise tests in pulmonary arterial hypertension
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 170134
DO 10.1183/16000617.0134-2017
VO 27
IS 148
A1 Stefania Farina
A1 Michele Correale
A1 Noemi Bruno
A1 Stefania Paolillo
A1 Elisabetta Salvioni
A1 Roberto Badagliacca
A1 Piergiuseppe Agostoni
A1 ,
YR 2018
UL http://err.ersjournals.com/content/27/148/170134.abstract
AB Despite recent advances in the therapeutic management of patients affected by pulmonary arterial hypertension (PAH), survival remains poor. Prompt identification of the disease, especially in subjects at increased risk of developing PAH, and prognostic stratification of patients are a necessary target of clinical practice but remain challenging. Cardiopulmonary exercise test (CPET) parameters, particularly peak oxygen uptake, end-tidal carbon dioxide tension and the minute ventilation/carbon dioxide production relationship, emerged as new prognostic tools for PAH patients. Moreover, CPET provides a comprehensive pathophysiological evaluation of patients' exercise limitation and dyspnoea, which are the main and early symptoms of the disease. This review focuses on the role of CPET in the management of PAH patients, reporting guideline recommendations for CPET and discussing the pathophysiology of exercise limitation and the most recent use of CPET in the diagnosis, prognosis and therapeutic targeting of PAH.CPET provides valuable information on diagnosis, prognosis and therapy in PAH but it should be performed by experts http://ow.ly/q5O230j6hta