TY - JOUR T1 - Tuberculosis and lung damage: from epidemiology to pathophysiology JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0077-2017 VL - 27 IS - 147 SP - 170077 AU - Shruthi Ravimohan AU - Hardy Kornfeld AU - Drew Weissman AU - Gregory P. Bisson Y1 - 2018/03/31 UR - http://err.ersjournals.com/content/27/147/170077.abstract N2 - A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high prevalence and its association with reduced quality of life. Importantly, specific host and pathogen factors causing lung impairment remain unclear. Host immune responses probably play a dominant role in lung damage, as excessive inflammation and elevated expression of lung matrix-degrading proteases are common during TB. Variability in host genes that modulate these immune responses may determine the severity of lung impairment, but this hypothesis remains largely untested. In this review, we provide an overview of the epidemiological literature on post-TB lung impairment and link it to data on the pathogenesis of lung injury from the perspective of dysregulated immune responses and immunogenetics.Host factors driving lung injury in TB likely contribute to variable patterns of pulmonary impairment after TB http://ow.ly/a3of30hBsxB ER -