PT  - JOURNAL ARTICLE
AU  - Guillaume Noell
AU  - Rosa Faner
AU  - Alvar Agustí
TI  - From systems biology to P4 medicine: applications in respiratory medicine
AID  - 10.1183/16000617.0110-2017
DP  - 2018 Mar 31
TA  - European Respiratory Review
PG  - 170110
VI  - 27
IP  - 147
4099  - http://err.ersjournals.com/content/27/147/170110.short
4100  - http://err.ersjournals.com/content/27/147/170110.full
SO  - EUROPEAN RESPIRATORY REVIEW2018 Mar 31; 27
AB  - Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, “omics” data and bioinformatic computing power. It paves the way forward towards “P4 medicine” (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2) elaborate on how P4 medicine has the potential to shift healthcare from reactive medicine (treatment of illness) to predict and prevent illness, in a revolution that will be personalised in nature, probabilistic in essence and participatory driven; 3) review the current state of the art of network (systems) medicine in three prevalent respiratory diseases (chronic obstructive pulmonary disease, asthma and lung cancer); and 4) outline current challenges and future goals in the field.Systems biology and network medicine have the potential to transform medical research and practice http://ow.ly/r3jR30hf35x