TY - JOUR T1 - Lung nodules: size still matters JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW DO - 10.1183/16000617.0025-2017 VL - 26 IS - 146 SP - 170025 AU - Anna Rita Larici AU - Alessandra Farchione AU - Paola Franchi AU - Mario Ciliberto AU - Giuseppe Cicchetti AU - Lucio Calandriello AU - Annemilia del Ciello AU - Lorenzo Bonomo Y1 - 2017/12/31 UR - http://err.ersjournals.com/content/26/146/170025.abstract N2 - The incidence of indeterminate pulmonary nodules has risen constantly over the past few years. Determination of lung nodule malignancy is pivotal, because the early diagnosis of lung cancer could lead to a definitive intervention. According to the current international guidelines, size and growth rate represent the main indicators to determine the nature of a pulmonary nodule. However, there are some limitations in evaluating and characterising nodules when only their dimensions are taken into account. There is no single method for measuring nodules, and intrinsic errors, which can determine variations in nodule measurement and in growth assessment, do exist when performing measurements either manually or with automated or semi-automated methods. When considering subsolid nodules the presence and size of a solid component is the major determinant of malignancy and nodule management, as reported in the latest guidelines. Nevertheless, other nodule morphological characteristics have been associated with an increased risk of malignancy. In addition, the clinical context should not be overlooked in determining the probability of malignancy. Predictive models have been proposed as a potential means to overcome the limitations of a sized-based assessment of the malignancy risk for indeterminate pulmonary nodules.Size and growth rate remain the main determinants of nodule management http://ow.ly/mtDB30gugUg ER -