PT  - JOURNAL ARTICLE
AU  - Rana Kanaan
AU  - Charlie Strange
TI  - Use of multitarget tyrosine kinase inhibitors to attenuate platelet-derived growth factor signalling in lung disease
AID  - 10.1183/16000617.0061-2017
DP  - 2017 Dec 31
TA  - European Respiratory Review
PG  - 170061
VI  - 26
IP  - 146
4099  - http://err.ersjournals.com/content/26/146/170061.short
4100  - http://err.ersjournals.com/content/26/146/170061.full
SO  - EUROPEAN RESPIRATORY REVIEW2017 Dec 31; 26
AB  - Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) play a fundamental role in the embryonic development of the lung. Aberrant PDGF signalling has been documented convincingly in a large variety of pulmonary diseases, including idiopathic pulmonary arterial hypertension, lung cancer and lung fibrosis. Targeting PDGF signalling has been proven to be effective in these diseases. In clinical practice, the most effective way to block PDGF signalling is to inhibit the activity of the intracellular PDGFR kinases. Although the mechanism of action of such drugs is not specific for PDGF signalling, the medications have a broad therapeutic index that allows clinical use. The safety profile and therapeutic opportunities of these and future medications that target PDGFs and PDGFRs are reviewed.An increasing role for PDGF signalling inhibitors in clinical trials for the treatment of various pulmonary diseases http://ow.ly/buaI30f9HcN