PT  - JOURNAL ARTICLE
AU  - Lukas Bubendorf
AU  - Sylvie Lantuejoul
AU  - Adrianus J. de Langen
AU  - Erik Thunnissen
TI  - Nonsmall cell lung carcinoma: diagnostic difficulties in small biopsies and cytological specimens
AID  - 10.1183/16000617.0007-2017
DP  - 2017 Jun 30
TA  - European Respiratory Review
PG  - 170007
VI  - 26
IP  - 144
4099  - http://err.ersjournals.com/content/26/144/170007.short
4100  - http://err.ersjournals.com/content/26/144/170007.full
SO  - EUROPEAN RESPIRATORY REVIEW2017 Jun 30; 26
AB  - The pathological and molecular classification of lung cancer has become substantially more complex over the past decade. For diagnostic purposes on small samples, additional stains are frequently required to distinguish between squamous cell carcinoma and adenocarcinoma. Subsequently, for advanced nonsquamous cell nonsmall cell lung carcinoma (NSCLC) patients, predictive analyses on epidermal growth factor receptor, anaplastic lymphoma kinase and ROS1 are required. In NSCLCs negative for these biomarkers, programmed death ligand-1 immunohistochemistry is performed. Small samples (biopsy and cytology) require “tissue” management, which is best achieved by the interaction of all physicians involved.Tissue management is required to perform diagnostic and predictive testing in nonsmall cell lung carcinoma http://ow.ly/Ogeq30adDvN