PT - JOURNAL ARTICLE AU - Fraser R. Millar AU - Sam M. Janes AU - Adam Giangreco TI - Epithelial cell migration as a potential therapeutic target in early lung cancer AID - 10.1183/16000617.0069-2016 DP - 2017 Mar 31 TA - European Respiratory Review PG - 160069 VI - 26 IP - 143 4099 - http://err.ersjournals.com/content/26/143/160069.short 4100 - http://err.ersjournals.com/content/26/143/160069.full SO - EUROPEAN RESPIRATORY REVIEW2017 Mar 31; 26 AB - Lung cancer is the most lethal cancer type worldwide, with the majority of patients presenting with advanced stage disease. Targeting early stage disease pathogenesis would allow dramatic improvements in lung cancer patient survival. Recently, cell migration has been shown to be an integral process in early lung cancer ontogeny, with preinvasive lung cancer cells shown to migrate across normal epithelium prior to developing into invasive disease. TP53 mutations are the most abundant mutations in human nonsmall cell lung cancers and have been shown to increase cell migration via regulation of Rho-GTPase protein activity. In this review, we explore the possibility of targeting TP53-mediated Rho-GTPase activity in early lung cancer and the opportunities for translating this preclinical research into effective therapies for early stage lung cancer patients.Preinvasive lung cancer cell migration is a potential novel therapeutic target in early lung cancer http://ow.ly/FJGm305JxMQ