RT Journal Article
SR Electronic
T1 Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 472
OP 486
DO 10.1183/16000617.0063-2016
VO 25
IS 142
A1 Anna C. Bibby
A1 Selina Tsim
A1 Nikolaos Kanellakis
A1 Hannah Ball
A1 Denis C. Talbot
A1 Kevin G. Blyth
A1 Nick A. Maskell
A1 Ioannis Psallidas
YR 2016
UL http://err.ersjournals.com/content/25/142/472.abstract
AB Malignant pleural mesothelioma is an aggressive malignancy of the pleural surface, predominantly caused by prior asbestos exposure. There is a global epidemic of malignant pleural mesothelioma underway, and incidence rates are predicted to peak in the next few years.This article summarises the epidemiology and pathogenesis of malignant pleural mesothelioma, before describing some key factors in the patient experience and outlining common symptoms. Diagnostic approaches are reviewed, including imaging techniques and the role of various biomarkers. Treatment options are summarised, including the importance of palliative care and methods of controlling pleural effusions. The evidence for chemotherapy, radiotherapy and surgery is reviewed, both in the palliative setting and in the context of trimodality treatment. An algorithm for managing malignant pleural effusion in malignant pleural mesothelioma patients is presented. Finally new treatment developments and novel therapeutic approaches are summarised.This article on mesothelioma describes pathogenesis, symptoms, diagnostic approaches and treatment options http://ow.ly/cjkb305aQGz