RT Journal Article SR Electronic T1 Cough in idiopathic pulmonary fibrosis JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 278 OP 286 DO 10.1183/16000617.0090-2015 VO 25 IS 141 A1 Mirjam J.G. van Manen A1 Surinder S. Birring A1 Carlo Vancheri A1 Vincent Cottin A1 Elisabetta A. Renzoni A1 Anne-Marie Russell A1 Marlies S. Wijsenbeek YR 2016 UL http://err.ersjournals.com/content/25/141/278.abstract AB Many patients with idiopathic pulmonary fibrosis (IPF) complain of chronic refractory cough. Chronic cough is a distressing and disabling symptom with a major impact on quality of life. During recent years, progress has been made in gaining insight into the pathogenesis of cough in IPF, which is most probably “multifactorial” and influenced by mechanical, biochemical and neurosensory changes, with an important role for comorbidities as well. Clinical trials of cough treatment in IPF are emerging, and cough is increasingly included as a secondary end-point in trials assessing new compounds for IPF. It is important that such studies include adequate end-points to assess cough both objectively and subjectively. This article summarises the latest insights into chronic cough in IPF. It describes the different theories regarding the pathophysiology of cough, reviews the different methods to assess cough and deals with recent and future developments in the treatment of cough in IPF.Latest insights into pathophysiology of cough, methods to assess cough and developments in treatment of cough in IPF http://ow.ly/YfVAH