TY - JOUR T1 - Therapeutic strategies in pneumonia: going beyond antibiotics JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 516 LP - 524 DO - 10.1183/16000617.0034-2015 VL - 24 IS - 137 AU - Holger Müller-Redetzky AU - Jasmin Lienau AU - Norbert Suttorp AU - Martin Witzenrath Y1 - 2015/09/01 UR - http://err.ersjournals.com/content/24/137/516.abstract N2 - Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches demonstrated to improve lung injury in experimental preclinical studies. However, at present specific preventive or curative strategies for the treatment of lung failure in pneumonia in addition to antibiotics are still missing. The aim of this mini-review is to give a short overview of some, but not all, adjuvant therapeutic strategies for pneumonia and its most important complications, sepsis and acute respiratory distress syndrome, and briefly discuss future perspectives.A review of preclinical and clinical research on adjuvant therapies for pneumonia http://ow.ly/OeiN3 ER -