RT Journal Article
SR Electronic
T1 Advances in asthma pathophysiology: stepping forward from the Maurizio Vignola experience
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 30
OP 39
DO 10.1183/09059180.10011114
VO 24
IS 135
A1 Maria R. Bonsignore
A1 Mirella Profita
A1 Rosalia Gagliardo
A1 Loredana Riccobono
A1 Giuseppina Chiappara
A1 Elisabetta Pace
A1 Mark Gjomarkaj
YR 2015
UL http://err.ersjournals.com/content/24/135/30.abstract
AB Maurizio Vignola was a superb and innovative researcher, who wrote seminal papers on the biology of airway epithelium in asthma. Inflammation and remodelling were the main topics of his research, mostly conducted in biopsy specimens from patients with asthma of variable severity, encompassing the entire spectrum of the disease from mild to severe asthma. His observations contributed to define the biology of asthma as we know it today, and opened the way to the personalised treatment of asthma. His group has successfully continued to investigate the biology and clinical aspects of bronchial asthma, with major interest in the clinical use of biomarkers to monitor disease activity, and in the development of new therapeutic perspectives. This review summarises the latest work on these topics proudly conducted by Maurizio's closest collaborators. The results indicate significant progress in our understanding of asthma in the last 10 years, in particular increased knowledge of the complex interaction between inflammatory and remodelling pathways, improved recognition of biological and clinical asthma phenotypes, and development of new treatment strategies, especially for patients with severe corticosteroid-resistant asthma. Biomarkers may help to define disease phenotypes and new treatment strategies for asthma http://ow.ly/G2Fl6