TY - JOUR T1 - Comorbidities of COPD JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 454 LP - 475 DO - 10.1183/09059180.00008612 VL - 22 IS - 130 AU - Arnaud Cavaillès AU - Graziella Brinchault-Rabin AU - Adrien Dixmier AU - François Goupil AU - Christophe Gut-Gobert AU - Sylvain Marchand-Adam AU - Jean-Claude Meurice AU - Hugues Morel AU - Christine Person-Tacnet AU - Christophe Leroyer AU - Patrice Diot Y1 - 2013/12/01 UR - http://err.ersjournals.com/content/22/130/454.abstract N2 - By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality. Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco smoking is a common risk factor for many comorbidities, including coronary heart disease, heart failure and lung cancer. Comorbidities such as pulmonary artery disease and malnutrition are directly caused by COPD, whereas others, such as systemic venous thromboembolism, anxiety, depression, osteoporosis, obesity, metabolic syndrome, diabetes, sleep disturbance and anaemia, have no evident physiopathological relationship with COPD. The common ground between most of these extrapulmonary manifestations is chronic systemic inflammation. All of these diseases potentiate the morbidity of COPD, leading to increased hospitalisations and healthcare costs. They can frequently cause death, independently of respiratory failure. Comorbidities make the management of COPD difficult and need to be evaluated and treated adequately. ER -