TY - JOUR T1 - Cellular interactions in the pathogenesis of interstitial lung diseases JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 102 LP - 114 DO - 10.1183/09059180.00003214 VL - 24 IS - 135 AU - Gianluca Bagnato AU - Sergio Harari Y1 - 2015/03/01 UR - http://err.ersjournals.com/content/24/135/102.abstract N2 - Interstitial lung disease (ILD) encompasses a large and diverse group of pathological conditions that share similar clinical, radiological and pathological manifestations, despite potentially having quite different aetiologies and comorbidities. Idiopathic pulmonary fibrosis (IPF) represents probably the most aggressive form of ILD and systemic sclerosis is a multiorgan fibrotic disease frequently associated with ILD. Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis. Distinct cell populations contribute to the complex pathogenesis of IPF and systemic sclerosis-associated ILD http://ow.ly/AjFaz ER -