PT  - JOURNAL ARTICLE
AU  - Gianluca Bagnato
AU  - Sergio Harari
TI  - Cellular interactions in the pathogenesis of interstitial lung diseases
AID  - 10.1183/09059180.00003214
DP  - 2015 Mar 01
TA  - European Respiratory Review
PG  - 102--114
VI  - 24
IP  - 135
4099  - http://err.ersjournals.com/content/24/135/102.short
4100  - http://err.ersjournals.com/content/24/135/102.full
SO  - EUROPEAN RESPIRATORY REVIEW2015 Mar 01; 24
AB  - Interstitial lung disease (ILD) encompasses a large and diverse group of pathological conditions that share similar clinical, radiological and pathological manifestations, despite potentially having quite different aetiologies and comorbidities. Idiopathic pulmonary fibrosis (IPF) represents probably the most aggressive form of ILD and systemic sclerosis is a multiorgan fibrotic disease frequently associated with ILD. Although the aetiology of these disorders remains unknown, in this review we analyse the pathogenic mechanisms by cell of interest (fibroblast, fibrocyte, myofibroblast, endothelial and alveolar epithelial cells and immune competent cells). New insights into the complex cellular contributions and interactions will be provided, comparing the role of cell subsets in the pathogenesis of IPF and systemic sclerosis. Distinct cell populations contribute to the complex pathogenesis of IPF and systemic sclerosis-associated ILD http://ow.ly/AjFaz