TY - JOUR T1 - Cystic fibrosis. Lung Biology in Health Disease, Vol. 242. JF - European Respiratory Review JO - EUROPEAN RESPIRATORY REVIEW SP - 352 LP - 353 VL - 19 IS - 118 AU - T. Kotsimbos Y1 - 2010/12/01 UR - http://err.ersjournals.com/content/19/118/352.abstract N2 - J.L. Allen, H.B. Panitch, R.C. Rubenstein Informa Healthcare 523 £125.00 978-1439801819“The search for truth is in one way hard and in another very easy. For it is evident that no-one can master it fully nor miss it wholly. But each adds a little to our knowledge of nature, and from all the facts assembled there arises a certain grandeur”Aristotle“The big picture is all in the detail”Charles DarwinThe quote from Aristotle is as appropriate now as it was when it appeared in the preface to the first volume addressing cystic fibrosis (CF) in this very successful series. How far we have come, and how far we still have to go!In 1993, we were still in the afterglow of unravelling the genetic abnormality of CF and how this related to pathophysiology and clinical syndromes. The future looked bright regarding understanding CF and having increased options to intervene and improve clinical outcomes. Over the ensuing 17 years this is exactly what happened but perhaps not in exactly the way predicted. CF outcomes have now improved dramatically, underpinned by developments in care and research at all points in the disease spectrum from early diagnosis/screening, through to nutritional and lung function maintenance, psychosocial health and advanced care, including the option of lung transplantation. If there was one standout discovery that characterises this period of improved CF care it is that enabling CF teams to focus on uncompromising excellence and vigilance in implementing, integrating and continuously incrementally improving all the “standard approaches in CF care” can have dramatic long-term benefits for CF patients.All those involved with this book should be congratulated on achieving their aims of “giving caregivers access to an increased understanding of the molecular basis of … ER -