RT Journal Article SR Electronic T1 Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 510 OP 518 DO 10.1183/09059180.00005114 VO 23 IS 134 A1 Marie-Christine Dombret A1 Khuder Alagha A1 Louis Philippe Boulet A1 Pierre Yves Brillet A1 Guy Joos A1 Michel Laviolette A1 Renaud Louis A1 Thierry Rochat A1 Paola Soccal A1 Michel Aubier A1 Pascal Chanez YR 2014 UL http://err.ersjournals.com/content/23/134/510.abstract AB Bronchial thermoplasty is a young yet promising treatment for severe asthma whose benefit for long-term asthma control outweighs the short-term risk of deterioration and hospitalisation in the days following the treatment. It is an innovative treatment whose clinical efficacy and safety are beginning to be better understood. Since this is a device-based therapy, the overall evaluation of risk–benefit is unlike that of pharmaceutical products; safety aspects, regulatory requirements, study design and effect size assessment may be unfamiliar. The mechanisms of action and optimal patient selection need to be addressed in further rigorous clinical and scientific studies. Bronchial thermoplasty fits in perfectly with the movement to expand personalised medicine in the field of chronic airway disorders. This is a device-based complimentary asthma treatment that must be supported and developed in order to meet the unmet needs of modern severe asthma management. The mechanisms of action and the type of patients that benefit from bronchial thermoplasty are the most important challenges for bronchial thermoplasty in the future.