RT Journal Article
SR Electronic
T1 A physiological model of patient-reported breathlessness during daily activities in COPD
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 66
OP 79
DO 10.1183/09059180.00000809
VO 18
IS 112
A1 C. J. Jolley
A1 J. Moxham
YR 2009
UL http://err.ersjournals.com/content/18/112/66.abstract
AB Breathlessness during daily activities has a significant impact on quality of life in chronic obstructive pulmonary disease. Herein, we present a physiological model of patient-reported breathlessness based on the relationship between ventilatory load, respiratory muscle capacity, neural respiratory drive and neuromechanical dissociation during daily activities. This model should facilitate an understanding of the mechanisms driving increased intensity of breathlessness during daily activities and the relief of breathlessness following medical or surgical interventions.The model should also provide a structure on which to base the development of patient-reported outcome instruments to measure the severity of breathlessness during daily activities in chronic obstructive pulmonary disease.