RT Journal Article SR Electronic T1 Does creatine supplementation enhance the effects of physical training during pulmonary rehabilitation in COPD? JF European Respiratory Review JO EUROPEAN RESPIRATORY REVIEW FD European Respiratory Society SP 187 OP 189 DO 10.1183/09059180.00010116 VO 15 IS 101 A1 SarahJ. Deacon A1 EmmaE. Vincent A1 SallyJ. Singh A1 MichaelC. Steiner A1 Paul Greenhaff A1 MichaelD. Morgan YR 2006 UL http://err.ersjournals.com/content/15/101/187.abstract AB We conducted a randomised, placebo-controlled trial to examine whether creatine supplementation augments the benefits of pulmonary rehabilitation (PR), containing aerobic exercise and resistance training (RT). 80 subjects with COPD (GOLD stages I–IV) [mean (SD) age 68 (7.8) yrs, FEV1 44.1 (20.3) % predicted] completed 21 sessions of PR, with enhanced RT, following baseline measurements and randomisation to take creatine (Cr) or placebo (Pl) supplement. A subgroup had muscle biopsies. Groups were well matched at baseline except for gender (M:F Cr 19:19, Pl 31:11, Chi2 p = 0.03). Mean change in functional performance & muscle strength after PR are shown. Health status (CRQ-SR) improved significantly after PR but did not differ between groups. Muscle biopsies showed evidence of creatine uptake. This adequately powered study showed significant improvements in all outcomes following PR. Creatine supplementation did not enhance these benefits.