RT Journal Article
SR Electronic
T1 Adult-onset asthma: is it really different?
JF European Respiratory Review
JO EUROPEAN RESPIRATORY REVIEW
FD European Respiratory Society
SP 44
OP 52
DO 10.1183/09059180.00007112
VO 22
IS 127
A1 Selma B. de Nijs
A1 Lisette N. Venekamp
A1 Elisabeth H. Bel
YR 2013
UL http://err.ersjournals.com/content/22/127/44.abstract
AB Asthma that starts in adulthood differs from childhood-onset asthma in that it is often non-atopic, more severe and associated with a faster decline in lung function. Understanding of the underlying mechanism of adult-onset asthma and identification of specific phenotypes may further our understanding of pathophysiology and treatment response, leading to better targeting of both existing and new approaches for personalised management. Pivotal studies in past years have led to sustained progress in many areas, ranging from risk factors for development, identification of different phenotypes, and introduction of new therapies. This review highlights and discusses literature on adult-onset asthma, with special focus on the differences from childhood-onset asthma, risk factors for development, phenotypes of adult-onset asthma and new approaches for personalised management.