PT  - JOURNAL ARTICLE
AU  - Selma B. de Nijs
AU  - Lisette N. Venekamp
AU  - Elisabeth H. Bel
TI  - Adult-onset asthma: is it really different?
AID  - 10.1183/09059180.00007112
DP  - 2013 Mar 01
TA  - European Respiratory Review
PG  - 44--52
VI  - 22
IP  - 127
4099  - http://err.ersjournals.com/content/22/127/44.short
4100  - http://err.ersjournals.com/content/22/127/44.full
SO  - EUROPEAN RESPIRATORY REVIEW2013 Mar 01; 22
AB  - Asthma that starts in adulthood differs from childhood-onset asthma in that it is often non-atopic, more severe and associated with a faster decline in lung function. Understanding of the underlying mechanism of adult-onset asthma and identification of specific phenotypes may further our understanding of pathophysiology and treatment response, leading to better targeting of both existing and new approaches for personalised management. Pivotal studies in past years have led to sustained progress in many areas, ranging from risk factors for development, identification of different phenotypes, and introduction of new therapies. This review highlights and discusses literature on adult-onset asthma, with special focus on the differences from childhood-onset asthma, risk factors for development, phenotypes of adult-onset asthma and new approaches for personalised management.