“Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice.” Stephen Y. Chan and Lewis J. Rubin. Eur Respir Rev 2017; 26: 170094.
Unfortunately, in this article in the December 2017 issue of the European Respiratory Review, the details about modulation of peroxisome proliferator-activated receptor (PPAR)γ at the end of the section “Hypoxia-inducible factor and downstream metabolic effectors relevant to the Warburg effect” were not entirely accurate. The final two sentences of this section have been rephrased as follows: “Despite these encouraging findings, the clinical use of older PPARγ agonists has been tempered by indications of adverse myocardial events [49] and has stymied advances in PH. Nonetheless, the weight of evidence regarding the activity of PPARγ in PH indicates its potential as a future drug target, particularly for newer PPARγ agonists [50].” The reference by Kernan et al. [50] has been added, and subsequent references have been renumbered. The article was corrected before printing the December 2017 issue, and has been corrected and republished online.
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