Abstract
Exposure to inhaled pollutants, including fine particulates and cigarette smoke is a major cause of lung disease in Europe. While it is established that inhaled pollutants have devastating effects on the genome, it is now recognised that additional effects on protein folding also drive the development of lung disease. Protein misfolding in the endoplasmic reticulum affects the pathogenesis of many diseases, ranging from pulmonary fibrosis to cancer. It is therefore important to understand how cells respond to endoplasmic reticulum stress and how this affects pulmonary tissues in disease. These insights may offer opportunities to manipulate such endoplasmic reticulum stress pathways and thereby cure lung disease.
Abstract
Endoplasmic reticulum stress may play a role in pathogenesis of pulmonary fibrosis and cancer http://ow.ly/Ys5k30bRmL5
Footnotes
Support statement: Stefan J. Marciniak has received funding from Medical Research Council UK (G1002610), Alpha 1 Foundation, British Lung Foundation and Papworth Hospital NHS Foundation Trust. Funding information for this article has been deposited with the Crossref Funder Registry.
Conflict of interest: None declared.
Provenance: Commissioned article, peer reviewed.
- Received March 8, 2017.
- Accepted May 15, 2017.
- Copyright ©ERS 2017.
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