Bateman [15] | Moderate to severe | As described in the EMSCI and NiSCI | Questionnaires (EMSCI and NiSCI) for the patients | 90.6% of all patients with COPD | NA | Most COPD patients with morning symptoms considered that their symptoms affect their morning activities |
Stephenson [20] | All stages | Time of getting out of bed and approximately 11:00 h | A 30-min questionnaire for patients about morning symptoms and the impact on morning activities | 60.4%# | Work§ | More than half of patients considered that their symptoms affect their morning activities |
Miravitlles [16] | All stages | Time of getting out of bed and approximately 11:00 h | Patients filled out a Night-time, Morning and Daytime Symptoms of COPD questionnaire, developed by the sponsor | Patients who are sedentary experience more symptoms in any part of the day (also in the morning); p<0.05 | NA | In each part of the day (morning, daytime, night time) there was an significant association between symptoms and a low physical activity level |
O’Hagan [19] | All stages | Not defined | Online questionnaire consisting predefined questions for patients | 34–79%# have problems with common morning activities; 56–70%# with more physically demanding activities | Self-care, domestic activities and work§ | Morning symptoms can severely compromise patients’ ability to perform, even simple tasks. Half of the patients had made changes to their morning routines |
Roche [17] | All stages | Symptoms that are present when getting up in the morning, thus those symptoms present on waking, rather than those persisting through the morning | Questionnaires with predefined questions. Physicians gave information about severity grade of the symptoms; patients about the impact on daily life | Impact on normal activities was higher in those with morning symptoms (3.96 versus 3.29+; p=0.007) | Self-care and work§ | Impact on daily activities was significantly higher in patients with morning symptoms than without |
Kim [18] | Severe to very severe | Not defined | Patients filled out the CSQ. Those who reported morning symptoms, subsequently completed the MAQ | 57% of all patients with COPD | Self-care and domestic activities§ | 57% of COPD patients had considerable impact on their morning activities |
Kessler [22] | Severe to very severe | In the morning, after waking up and later in the morning | Interview over the telephone. Predefined questions developed by the sponsor | 35.4–41.0% of patients that experience any symptom felt that morning symptoms affect morning activities | Self-care§ | There was an association between morning symptoms and the impact on activities |
Partridge [21] | All stages | From the time they woke up until they were dressed, had breakfast and were ready to start the day | Predefined questions were answered by the patient by an internet interview | 37% of all COPD patients and 73% of the severe¶ COPD patients regarded problems associated with morning routines as bothersome. 74% of all COPD patients and 96% of the severe¶ patients reported that they took longer to complete their morning routines | Self-care and domestic activities§ | Many patients considered the impact of COPD on morning activities to be extensive |