Di Sario et al. [79] | Primary rat hepatic stellate cells | Inhibited PDGF-stimulated proliferation | Reduced TGF-β induced collagen I (protein and mRNA) | |
Ozes and Blatt [80] | Human lung fibroblasts (HFL-1) | | Reduced TGF-β induced collagen (protein) | |
Sulfab et al. [81] | Human unbilical vein endothelial cells (HUVEC) | | Reduced TGF-β stimulated fibronectin, collagen IV, and thrombospondin-2 proteins# | Reduced TGF-β stimulated ET-1, IGFBP-3 and TGF-β isoforms 1-3 |
Nakayama et al. [82] | Normal human lung fibroblasts (NHLF) | | Reduced TGF-β induced collagen I expression (protein and mRNA) | Reduced TGF-β induced expression of the collagen chaperone HSP47 (protein and mRNA) |
Zhang et al. [83] | Human retinal pigment epithelial (RPE) cells | | Reduced TGF-β induced fibronectin (protein) production | |
Hewitson et al. [84] | Rat renal fibroblast isolated after ureteral obstruction (a mixture of fibroblasts and myofibroblasts) | Reduced fibroblast proliferation | Collagen protein production unaffected (slight reduction) | Reduced α-SMA and CTGF protein expression |
Lin et al. [85] | Human tenon’s fibroblasts (isolated from eye and expanded) | Reduced serum-stimulated fibroblast proliferation. Increased population of G1-phase cells and decreased S-phase. | | Reduced TGF-β1, -β2, and -β3 mRNA and protein expression; reduced fibroblast migration and collagen matrix contraction |
Lee et al. [86] | Human myometrial and leiomyoma smooth muscle cells (benign uterine fibroid tumour cells) | Reduced serum-stimulated fibroblast proliferation | Reduced collagen I and III mRNA expression | |