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NRAD fBOS Airway inflammation Neutrophils No neutrophils Clinical picture Crackles, increased sputum production No crackles, little sputum Time after transplantation Early Late Course Slowly, several years Fast, 6 months Histology Initially inflammation, finally fibrosis Merely fibrotic AZI therapy Beneficial/reversible Not beneficial/irreversible

NRAD: neutrophilic reversible allograft dysfunction; fBOS: fibropoliferative bronchiolitis obliterans syndrome; AZI: azithromycin.

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