Table 1— Control and monocrotaline(MCT) treated rats
|
Control
|
MCT+vehicle
|
MCT+sorafenib
|
| RVP mmHg |
27.0±0.5* |
82.9±6.0 |
35.0±1.5* |
| RVEDP mmHg |
2.0±0.2* |
7.7±1.3 |
2.6±0.2* |
| RV/(LV+S) |
0.24±0.01* |
0.51±0.02 |
0.26±0.01* |
| CO mL·min–1 |
116.1±5.1* |
70.5±6.7 |
117.4±5.3* |
| Pa,O2 mmHg |
204.8±18.5* |
107.7±13.8 |
200.0±10.4* |
|
Data are presented as mean±SEM. RVP: right ventricular pressure; RVEDP: right ventricular end-diastolic pressure; RV/(LV+S): ratio of right ventricle to left ventricle plus sputum; CO: cardiac output; Pa,O2: arterial oxygen tension. In each group, n = 12–14. *: p<0.05 versus vehicle.
|
