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Update on the roles of distal airways in asthma

For affiliations, please see the Acknowledgements section

CORRESPONDENCE: D. Dusser, Service de Pneumologie, Hôpital Cochin, 27 rue du Faubourg, St Jacques 75679, Paris Cedex 14, France. E-mail: daniel.dusser{at}cch.aphp.fr

Received: March 4, 2009
Accepted March 6, 2009

ABSTRACT

The present review is the summary of an expert workshop that took place in Vence (France) in 2007 on the role of distal airways in asthma. The evidence showing inflammation and remodelling in distal airways, and their possible involvement in asthma control and natural history, was reviewed. The usefulness and limitations of various techniques used for assessing distal airways were also evaluated, including pulmonary function tests and imaging. Finally, the available data studying the benefit of treatment better targeting distal airways in asthma was examined. It was concluded that both proximal and distal airways were involved in asthma and that distal airways were the major determinant of airflow obstruction. Inflammation in distal airways appeared more intense in severe and uncontrolled asthma. Distal airways were poorly attained by conventional aerosol of asthma medications owing to their granulometry, being composed of 3–5 µm particles. Both proximal and distal airways might be targeted either by delivering medications systemically or by aerosol of extra-fine particles. Extra-fine aerosols of long-acting β-agonists, inhaled corticosteroids or inhaled corticosteroid/long-acting β-agonist combinations have been shown in short-term studies to be not inferior to non-extra-fine aerosols of comparators. However, available studies have not yet demonstrated that extra-fine inhaled medications offer increased benefit compared with usual aerosols in asthmatic patients.

KEYWORDS: Airway inflammation, airway remodelling, alveoli, asthma, bronchioles, distal airway