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Pulmonary necrobiotic nodules: a rare extraintestinal manifestation of Crohn's disease

G. Warwick^*, T. Leecy^#, E. Silverstone^¶, S. Rainer, R. Feller and D. H. Yates^*

^* Depts of Thoracic Medicine, ^¶ Radiology, Histopathology, Gastroenterology, St Vincent's Hospital, and ^# Dept of Histopathology, Royal North Shore Hospital, Sydney, Australia.

CORRESPONDENCE: D. H. Yates, Dept of Thoracic Medicine, St Vincent's Hospital, 390 Victoria Street, Darlinghurst, NSW 2010, Australia. Fax: 612 8382 2359. E-mail: deborahy88{at}hotmail.com

Received: October 8, 2008
Accepted December 1, 2008

ABSTRACT

The present article reports the case of a 22-yr-old female with new onset Crohn's colitis, anterior uveitis and multiple pulmonary nodules which, on histological examination, were necrobiotic nodules. This is a rare but recognised pulmonary extraintestinal manifestation of Crohn's disease and only the fourth reported case. The present case report is followed by a brief review of the relevant literature.

KEYWORDS: Crohn's disease, high-resolution computed tomography, interstitial lung disease, necrobiotic nodules