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Quantitative morphology of compensatory lung growth

CORRESPONDENCE: Dept. of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9034, USA, Fax: 1 2146488027. E-mail: Connie.Hsia{at}utsouthwestern.edu

Compensatory lung growth is defined by the absolute increases in the quantity of functioning lung tissue in response to injury and/or disease, leading to a positive impact on functional outcome. The pneumonectomy model is used as an example to illustrate the salient features of compensatory growth and the specific considerations in its morphological quantification, including techniques of sampling and analysis, resolution of ultrastructural details, selection of markers for measurement, and interpretation of results in the context of organ architecture and physiology. The potential for structure–function dissociation is described in the present article. The current paper will discuss the application of high-resolution computed tomography to noninvasively quantify regional anatomy as well as temporal evolution of lung growth.

KEYWORDS: Airway, diffusing capacity, high-resolution computed tomography, lung alveoli, morphometry, pneumonectomy