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Stereological analysis of acute lung injury

CORRESPONDENCE: M. Ochs, Institute of Anatomy, Experimental Morphology, University of Bern, Baltzerstrasse 2, CH-3012 Bern, Switzerland. Fax: 41 316313807. E-mail: ochs{at}ana.unibe.ch

Acute lung injury is associated with a variety of histopathological alterations, such as oedema formation, damage to the components of the blood–air barrier and impairment of the surfactant system. Stereological methods are indispensable tools with which to properly quantitate these structural alterations at the light and electron microscopic level. The stereological parameters that are relevant for the analysis of acute lung injury are reviewed in the present article.

KEYWORDS: Acute lung injury, microscopy, morphometry, stereology